A drug that eliminates typhoid fever by 99.9 %

An American study revealed that a common antibiotic, known as Rifampin, has proven effective by 99.9 percent against bacteria causing typhoid fever.
Researchers at Cornell University, during the study, whose results were published, on Monday, in the journal (Ebiomedicine) that these results open the door to effective treatment for severe and resistant infections of multiple drugs of typhoid fever.
typhoid fever is a serious bacterial infection caused by salmonella bacteria, and causes the death of more than 150,000 people annually worldwide. It is often transmitted by eating contaminated food or drink, and it is a common health problem in countries with weak health and water infrastructure, and may lead to life -threatening complications if not treated.
An accurate diagnosis and rapid treatment of antibiotics is a key to reducing death rates and controlling the spread of the disease, especially with the increasing breeds of treatment.
The research team tested the medicine “Reifampine”, which is approved by the American Food and Drug Administration, and included in the World Health Organization’s basic medicine list, and is currently used to treat travelers ’diarrhea, which indicates that it can soon adopt an option to treat typhoid.
The researchers suggest that the reason for the previously ignoring the "Reifampine" is a treatment for the tinyid due to the emergence of resistance to it in cases of tuberculosis. However, the results of the study showed that more than 99.4 percent of the clinical insulation of typhoid bacteria are still sensitive to the antibiotic, at a rate of 99.91 percent.
The researchers discovered that Riverpine is working in an innovative way; It removes the outer cover of bacteria, known as capsule, which protects it from the immune system, and helps it to form virgin membranes and antibiotic resistance.
The bacterial capsule is one of the most important factors of bacteria. It enables it to infect the body and escape the immune response, and the type in typhoid bacteria is more related to death and more drug -resistant.
But the research team found that "Riverpine" removes this capsule even in the strains very infected, which facilitates the immune system to identify and eliminate bacteria, and then enhance the chances of survival in patients.
The genetic data collected by the researchers indicates that the mechanism of removing the capsule that characterizes Riverpine may also apply to other bacteria covered with similar capsules, such as bacteria that cause pneumonia and meningitis.
The team intends to continue its research to focus on combining capsule removal medications and drugs targeting «typhoid poison», one of the most important factors that help bacteria to develop the body, with the aim of developing multiple treatment solutions against the disease.
The team confirms that effective treatment, in parallel with vaccination campaigns, is a decisive element in eliminating typhoid fever, and supporting global efforts to control its spread in the affected areas.